Host Lewis phenotype‐dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys
نویسندگان
چکیده
منابع مشابه
Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice
Variation of surface antigen expression is a mechanism used by microbes to adapt to and persist within their host habitats. Helicobacter pylori, a persistent bacterial colonizer of the human stomach, can alter its surface Lewis (Le) antigen expression. We examined H. pylori colonization in mice to test the hypothesis that host phenotype selects for H. pylori (Le) phenotypes. When wild-type and ...
متن کاملHelicobacter pylori does not require Lewis X or Lewis Y expression to colonize C3H/HeJ mice.
Helicobacter pylori strains frequently express Lewis X (Le(x)) and/or Le(y) on their cell surfaces as constituents of the O antigens of their lipopolysaccharide molecules. To assess the effect of Le(x) and Le(y) expression on the ability of H. pylori to colonize the mouse stomach and to adhere to epithelial cells, isogenic mutants were created in which fucT1 alone or fucT1 and fucT2, which enco...
متن کاملSTOMACH Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection
suggests that colesevelam may be beneficial for patients with diarrhoea who have undergone small bowel resection forCrohn’s disease. There are no other published data to support its role in bile salt induced diarrhoea. Colesevelam is reported to be 4–6 times as potent as traditional bile salt sequestrants, possibly due to its greaterbinding affinity for glycocholic acid. It is administe...
متن کاملHost gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection.
BACKGROUND AND AIMS We tested if host gastric Lewis antigens and the babA2 genotype of Helicobacter pylori correlated with clinicohistological outcome. METHODS We enrolled 188 dyspeptic patients (45 with duodenal ulcer, 45 with gastric ulcer, and 98 with chronic gastritis) with H pylori infection, proved by culture and gastric histology, reviewed by the updated Sydney system. Gastric expressi...
متن کاملLewis antigen expression and stability in Helicobacter pylori isolated from serial gastric biopsies.
The expression of Lewis antigens by the gastric pathogen Helicobacter pylori in serial biopsy isolates was investigated to assess antigen distribution and stability. A total of 26 asymptomatic subjects were given various doses of 3' sialyllactose for up to 56 days. Gastric biopsies were performed during the dosing period, as well as 30 days after dosing, which provided 127 H. pylori isolates th...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.05-5529fje